Virginia Commonwealth University
Dr. Shijun Zhang is an Assistant Professor, Department of Medicinal Chemistry, VCU (2007 - Present) and also worked as Research Associate, Department of Medicinal Chemistry, University of Minnesota (2005 - 2007)
Alzheimer′s disease; MAPKs inhibitors and their application in cancer and neuro degeneration disease, rational drug design 1. One of our research interests focuses on the development of novel ligands as potential treatment agents for Alzheimer & primes disease (AD). Specifically, we use bivalent ligand stratety to develop multifunctional ligands they target beta-amyloid oligomers, the potential causative species of AD, oxidative stress, bimetals and cell membrane/lipid rafts. The research involves rational design, organic synthesis, in vitro and in vivo biological charaterization. 2. Deregulation of signalling pathways have been indicated to play important roles in the tumorigenity and drug resistance of human cancers, among which the Raf/MEK/ERK and the PI3K/Akt pathways have been well characterized.