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conferenceseries.com
Volume 7, Issue 4 (Suppl) Otolaryngology
ISSN: 2161-119X Otolaryngology, an open access journal Aesthetic Medicine & ENT Conference 2017
July 06-08, 2017
July 06-08, 2017 Kuala Lumpur, Malaysia
International Conference on
Aesthetic Medicine and ENT
The utility of stem cells in Alopecia areata: A five year experience
Marwa Mohamed Fawzy
Cairo University, Egypt
Background: Alopecia areata (AA) is a common condition causing non-scarring hair loss, yet its pathogenesis is still unclear.
Treatment of AA is a difficult challenge. The discovery of epithelial stem cells in the bulge region of the outer root sheath of
hair follicles in mice and man has encouraged researchers to utilize the hair follicle as a therapeutic source of stem cells for
regenerative medicine.
Objective: The objective of the study is to evaluate the use of follicular stem cells in the treatment of AA.
Patients & Methods: Fifteen patients with AA of the scalp were included in a randomized controlled double blinded clinical
trial. Isolation of hair follicle stem cells was done by enzymatic digestion of the bulge areas. Cell tagging using iron oxide
particles was performed in order to elucidate the exact fate of the injected cells as a way for in vivo cell tracking. Sham saline
injections have been done at control sites on the scalp of the treated patients.
Results: Excellent response was achieved in three patients (20%), good response was achieved in seven patients (47%), while
five patients (33%) showed poor response at the end of nine months evaluation. None of the placebo injected sites in all
included patients showed any response.
Limitations: Sample size is relatively small. Long-term follow up is mandatory.
Conclusion: It can be concluded that, local follicular stem cell therapy could be a feasible, efficient and safe therapeutic option
for Alopecia areata.
Biography
Marwa Mohamed Fawzy has completed her PhD from Cairo University and Postdoctoral studies from Cairo University School of Medicine. She is a Professor of
Dermatology, Cairo University (since April 2016). She has got International Board Certificate in Dermatopathology (December 2010) passing successfully the 8th
International Board Certifying Examination in Dermatopathology. She has published more than 30 papers in reputed journals and has been serving as an Editorial
Board Member of repute.
Marwa Mohamed Fawzy, Otolaryngology 2017, 7:4 (Suppl)
DOI: 10.4172/2161-119X-C1-019