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Volume 7, Issue 4 (Suppl) Otolaryngology
ISSN: 2161-119X Otolaryngology, an open access journal Aesthetic Medicine & ENT Conference 2017
July 06-08, 2017
July 06-08, 2017 Kuala Lumpur, Malaysia
International Conference on
Aesthetic Medicine and ENT
Predictors of locoregional recurrence in early stage buccal cancer with pathologically clear surgical
margins and negative neck
Shakeel-Uz-Zaman, Shakil Aqil and Mohammad Ahsan Sulaiman
Liaquat National Hospital & Medical College, Pakistan
Objective: The purpose of this study was to identify the significant predictors of locoregional recurrence in early stage SCCA
of buccal mucosa with pathologically clear surgical margins and negative neck.
Materials & Methods: We retrospectively reviewed records of 73 patients who underwent per oral wide excision and
supraomohyoid neck dissection for early stage buccal SCCA between 2007 and 2011 with clear surgical margins (>5 mm
margins each) and negative neck (N0). None of the patients received postoperative radiotherapy or chemotherapy. The primary
endpoint of the study was local, regional or locoregional recurrence. Univariate and multivariate analyses were used to identify
independent predictors of locoregional recurrence.
Results: Recurrence was observed in 22 of 73 (30%) patients at the end of this study. Twelve (54.5%) had local, seven (31.8%)
had regional and three (13.6%) developed locoregional recurrences. Sixteen patients (72.2%) had recurrence within the first 2
years of primary treatment. Both univariate and multivariate analyses demonstrated that lymphovascular invasion (LVI) and
non-T4 muscular invasion (non-T4MI) were independent predictors affecting locoregional control.
Conclusion: Our results demonstrate that LVI and non-T4MI significantly increased the locoregional recurrence rate in
early stage buccal SCCA with clear surgical margins and negative nodal status. Adjuvant treatment with either radiation or
chemoradiation should be considered when one or both of these factors present.
Biography
Shakeel Uz Zaman completed his MBBS from King Aga Khan University, Later he joined for specialization of Otorhinolaryngology at Liaquat National Hospital &
Medical College, Karachi, Pakistan.
Shakeel-Uz-Zaman et al., Otolaryngology 2017, 7:4 (Suppl)
DOI: 10.4172/2161-119X-C1-019