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conferenceseries

.com

Volume 8, Issue 9 (Suppl)

J Clin Exp Cardiolog, an open access journal

ISSN: 2155-9880

Euro Cardiology 2017

October 16-18, 2017

October 16-18, 2017 | Budapest, Hungary

European

Cardiology

Conference

J Clin Exp Cardiolog 2017, 8:9(Suppl)

DOI: 10.4172/2155-9880-C1-078

SIRS and sepsis: Differences in the inflammatory response

Julie Benbenishty

Hadassah-Hebrew University Medical Center, Israel

he effect of sex/gender in critical illness outcomes is controversial. We aimed to systematically review evidence on the

influence of sex on outcomes of adult critically ill patients with sepsis and/or multiple organ dysfunctions, as reported

in published studies specifically including investigation of the effect of sex among their aims. The incidence of sepsis is lower

among women in the US general population for all infection sources except the genitourinary tract. The greater immune

system activity in women than in men is consistent with better survival in women with severe sepsis. Sex hormones or sex-

related gene polymorphisms may protect women against sepsis and death from sepsis. Estrogens and androgens are involved

in the pathogenesis of disease; both exogenous and endogenous estrogens are strong stimulators of cytokine production and

disease activity. This presentation will provide insight into understanding the gender differences in SIRS and sepsis and how to

administer different treatment regimens based on gender. Although results of data syntheses appear to point towards a small

disadvantage for survival among women, our results suggest that data on the impact of sex/gender on ICU outcomes remain

equivocal. Implications for future research include approaches to adjustment for confounders, expanded outcome measures,

prospective designs and elucidation of the underlying pathophysiological framework. The relevance of this presentation to

European practice is that nurses will be able to assess, identify and treat patients suffering from inflammation with focused

gender care.