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Journal of Glycobiology | ISSN: 2168-958X | Volume 7
Glycobiology & Glycoproteomics
5
th
International Conference on
&
August 27-28, 2018 | Toronto, Canada
Molecular Biology & Nucleic Acids
3
rd
International Conference on
Dynamic aspects of the half-life of drugs, preclinical biomarkers-un update
Admir Nake,
and
Elizana Petrela
University of Medicine, Albania
Introduction:
Half-life of drugs, useful substances( lab exams, calibrators, biomarkers), after the validation process, have the
great application status in medical practice. Very important achieving to modify half-life of these “important substances” is
direct contributors to the efficacy of treatment, different clinical decision and improving life or quality of life of the patient and
more.
Aim:
Importance and feature of the half-life of drugs, lab exams, reagent and calibrators, and ways to modify and affect that.
We should know main “pits stops” affected half-life of drugs, functional group role, steric effect, polarization of molecules,
(as if voltaren vs fenoprofen, carbamazepine vs oxcarbamazepine, testosterone vs methyltestosterone), interacting factors,
responsible events (microbiome and clearance role), responsible organs (liver, kidney etc.), and importance of ways to modify
half-life of them. Half-life of circulating substances is important to select biomarkers such as for myocardial infarction(
ischemia modified albumin, myoglobin, CK, CK-MB, troponin, LDH), inflammatory biomarkers (soluble fraction of CD14,
pentraxin-3, procalcitonin, C-reactive protein) indicators of nutritional status( retinol binding protein, prealbumin, transferrin,
albumin). And glycosylated NT-proBNP ( natriuretic peptide) as calibrator.
Conclusion:
Biochemical events or “biochemical intervention” (conjugation, lipidation, PEG and HES methods, albumedix,
cell penetration peptides or dendrimers), modify features of drugs and lab or imagery biomarkers and the ways of their
applications. They’ve broken taboo of “static frame” of these important substances”, and are very useful “window”, have brought
new useful discoveries, new drugs, new lab and imagery biomarkers or methods as direct contributors in efficacy of treatment,
different clinical decision and improving life or quality of life of the patient and more.
Biography
Expertise in lab, medicine, especially microscopy, imunoenzymology, biochemistry exams, biomarkers, lab as a part of public health policy in Albania, improving and
updating point of view in diagnosis, screening and prognosis criteria, education and curricula of lab, tech staff, environment projects and application of principles
of Aarhus convention.
admir.nake@umed.edu.alAdmir Nake et al., J Glycobiol 2018, Volume 7
DOI: 10.4172/2168-958X-C1-012