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Journal of Glycobiology | ISSN: 2168-958X | Volume 7
Glycobiology & Glycoproteomics
5
th
International Conference on
&
August 27-28, 2018 | Toronto, Canada
Molecular Biology & Nucleic Acids
3
rd
International Conference on
Glycosyl cation: From observation to mimicry
Y Bleriot
University of Poitiers, France
G
lycosyl cations are crucial intermediates formed during enzymatic and chemical glycosidic bond formation and hydrolysis.
The high reactivity and short lifetime of these reaction intermediates make them very challenging to characterize using
spectroscopic techniques. Their observation is thus of high current interest to both gain insight into the mechanistic pathways of
SN1-like glycosylation at the atomic level and to design potent inhibitors of the glycoside processing enzymes that go through such
cationic intermediates by mimicry. Using super acidic conditions, we have been able to recently observe such chemical species is
their polyprotonated form in a condensed phase and to have access to their confirmation. Our most recent results dealing with this
approach will be presented as well as our parallel efforts to design potent glycosidase inhibitors mimicking such cationic intermediates
in order to target enzymes of therapeutic interest.
yves.bleriot@univ-poitiers.frJ Glycobiol 2018, Volume 7
DOI: 10.4172/2168-958X-C1-012