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Journal of Pharmaceutical care and Health Systems | ISSN: 2376-0419 | Volume 5
Pharmaceutical sciences
11
th
World Congress on
September 28-29, 2018 | Montreal, Canada
Formulation and characterization of hydrophilic drug Tramadol Hydrochloride nanoparticles in
transdermal drug delivery system
Mina Abbasnia
Hamedan university of medical science, Iran
T
ramadol Hydrochloride is a synthetic Opioid analgesic, with a suitable effect on cancer and post-op pains. Its addiction and
short half-life make it hard to use. Its main metabolite (O-des methyl Tramadol) is a pure agonist of µ receptors and the cause
of addiction. Transdermal Drug Delivery System (TDDS), is a delivery system that can control the drug release perfectly and it has
no First Pass Metabolism (FPM) and is non-invasive. In order to modify this delivery system features, Solid Lipid Nanoparticles
(SLNs) can be used as the carrier of choice. Tramadol Hydrochloride loaded SLNs were prepared using Double Emulsification-
Solvent Evaporation technique and a Central-Composite design, based on two independent variables (lipid/soy lecithin ratio and
the amount of drug), which used to reduce the number of required experiments. In order to examine the experimental design
method, Polydispersity index (PdI), particle size, Zeta potential, Entrapment and Loading efficiency and
In-vitro
release studies
were determined using a Zetasizer NanoZS and HPLC system. Also, the microscopic pictures of the particles were taken using a
Transmission Electronic Microscope. The optimum results for Tramadol HCl loaded SLNs were as follows: Size: 197 nm, PdI: 0.21,
Zeta: -19.8, EE: %89.4, LE: %9.74. Also, up to 30 % of incorporating drug was released from optimized SLNs in the initial period of
6 h and up to 40 % of the drug was released in a period of 24 h, and according to these results, the SLNs formulation follows Fickian
diffusion. Also, the TEM images showed a nearly spherical shape of the particles. As a result, there was no significant difference
between calculated and measured data, Tramadol HCl loaded SLNs can be used as a local analgesic. Although Further experiments
(specially pharmaceutical and pharmacological) will be needed in order to use this product clinically.
J Pharma Care Health Sys 2018, Volume 5
DOI: 10.4172/2376-0419-C3-033