Advanced Approach in Cell Signaling

The goal of research in signal transduction is to identify the functions of various signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made crucial grants to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the connections of omics techniques, huge progress has been made in understanding signaling networks. Advanced approach of cell signaling includes protein profiling and phosphorylation profiling and in this section also has molecular profiling which includes genomics proteomics and post translation modifications. By the process of cell signaling pathwaysHIV may be cured.

The use of procedures for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation, help to settle down some general regulatory characteristics of multi-tiered signaling cascades, and illuminate the combinatorial nature of signaling specificity in cell differentiation. Cellular kinase signal transduction pathways are involved in the regulation of many important cellular processes such as cell survival, differentiation and apoptosis. Kinase signaling networks are generally characterized by multiple kinases arranged in cascades containing nodes with feedback loops, and crosstalk between pathways. Advance approach mainly includes structure–function relationship and therapeutic potential of extracellular matrix macromolecules, ECM-mediated tissue organization in health and disease, ECM-mediated cell signaling and behavior, in expression and determination of various macromolecules with biopharmaceutical importance, and novel aspects of cell imaging.

  • Protein profiling and phosphorylation profiling
  • Molecular profiling including genomics, proteomics, and post translational modifications
  • Molecular perturbation including genetic and functional perturbations
  • Key signaling networks in cancer
  • Cell signaling pathways and HIV therapeutics

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