Advancements in Neuro-Oncology

In low-grade Gliomas, stereotactically guided conformal Radiotherapy should lead to a significant reduction in Radiation-associated late toxicity, while in selected groups of high-grade Gliomas the use of adjuvant or Neo-adjuvant Chemotherapy may improve survival. In primitive Neuroectodermal Tumours Prognostic Biological markers have been identified that are undergoing prospective evaluation. In infants the use of post-surgical chemotherapy alone may allow the postponing of Radiotherapy in selected cases. For patients with localized Medulloblastomas a new standard treatment is emerging that uses reduced-dose Craniospinal Radiotherapy followed by Platinum-based chemotherapy, while in Supratentorial primitive Neuroectodermal tumours future treatment will be aimed at improving local control.

  • Central Nervous System Malignancies
  • Primitive Neuroectodermal Tumours
  • platinum-based chemotherapy
  • Whole-brain radiotherapy (WBRT)

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