Antibody-mediated disorders

In antibody-mediated inflammatory disease, B cells (unique white blood cells) produce antibodies against the body's own structures; these are called auto-antibodies. When auto-antibodies bind to these structures, they induce unnecessary inflammation that is directed against healthy tissue. Autoantibodies directed against structures in the brain lead to irritation and swelling of brain tissue. If not treated, long standing inflammation can lead to permanent brain damage and dysfunction.

Antibogy Mediated Disorder  is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Prominent examples include Celiac diseasediabetes mellitus type 1Sarcoidosissystemic lupus erythematosus (SLE), Sjögren's syndromeChurg-Strauss SyndromeHashimoto's thyroiditisGraves' diseaseidiopathic thrombocytopenic purpuraAddison's Diseaserheumatoid arthritis (RA), Polymyositis (PM), and Dermatomyositis (DM). Autoimmune diseases are very often treated with steroids.

The misconception that an individual's immune system is totally incapable of recognizing self antigens is not new. Paul Ehrlich, at the beginning of the twentieth century, proposed the concept of horror autotoxicus, wherein a "normal" body does not mount an immune response against its own tissues. Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. Now, it is accepted that autoimmune responses are an integral part of vertebrate immune systems

  • Amyotrophic lateral sclerosis
  • Neuromyelitis optica
  • Schizophrenia
  • Transverse myelitis
  • CNS autoimmunity
  • Guillain-barre syndrome
  • Neurocystercercosis

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