Antigen Processing And Presentation

Antigen processing and presentation is the process by which protein antigen is ingested by an antigen-presenting cell (APC), partially digested into peptide fragments and then displayed on the surface of the APC associated with an antigen-presenting molecule such as MHC class I or MHC class II, for recognition by certain lymphocytes such as T cells. Antigen processing  involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e.g. viruses), or from phagocytosed pathogens (e.g. bacteria); subsequent presentation of these antigens on class I or class II major histocompatibility complex (MHC) molecules is dependent on which pathway is used.

  • MHC Structure, Function and Ligands
  • MHC Assembly and Trafficking
  • Mechanisms of Cross Presentation
  • Intracellular Events in Antigen Processing
  • Antigen Presenting Cells
  • Structure/Function Studies of Antigen Processing and Presentation

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