Antigenic Variation of Flu/ Influenza Virus

The explosive nature of epidemic flu and the specific clinical features of this disease have given definitive epidemiological records of this infection since the beginning of the nineteenth century. Some of the epidemics were recorded during the nineteenth century but the first pandemic was not precisely recorded until 1889-92. A second pandemic, probably originating in Europe, occurred in 1918-19, and is called as Spanish Influenza. It is responsible for 20-25 million deaths, principally in young adults. It was suggested that this strain had unusual virulence.

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