Bio Markers in Drug Designing

Biomarkers are key molecular or cellular events that link a specific environmental exposure to a health outcome. Biomarkers play an important role in understanding the relationships between exposure to environmental chemicals, the development of chronic human diseases, and the identification of subgroups that are at increased risk for disease. Much progress has been made in identifying and validating new biomarkers that can be used in population-based studies of environmental disease.

Biomarkers are key molecular or cellular events that link a specific environmental exposure to a health outcome. Biomarkers play an important role in understanding the relationships between exposure to environmental chemicals, the development of chronic human diseases, and the identification of subgroups that are at increased risk for disease. Much progress has been made in identifying and validating new biomarkers that can be used in population-based studies of environmental disease.

Tumor markers are substances that are produced by cancer or by other cells of the body in response to cancer or certain benign (noncancerous) conditions. Most tumor markers are made by normal cells as well as by cancer cells; however, they are produced at much higher levels in cancerous conditions. These substances can be found in the blood, urine, stool, tumor tissue, or other tissues or bodily fluids of some patients with cancer. Most tumor markers are proteins. However, more recently, patterns of gene expression and changes to DNA have also begun to be used as tumor markers. Many different tumor markers have been characterized and are in clinical use. Some are associated with only one type of cancer, whereas others are associated with two or more cancer types. No “universal” tumor marker that can detect any type of cancer has been found.

  • Biomarker Assay Development and Validation 
  • Genomic Biomarker Discovery
  • Incorporating Biomarkers into Drug Discovery and Development
  • Role of Biomakers in Drug Discovery
  • Challenges of Biomarkers in Drug Discovery and Development
  • Biomarker Discovery & Identification Strategies
  • Applications of Imaging Biomarkers
  • Safety, Efficacy, and PK/PD Biomarkers in Drug Development
  • Companion Diagnostics Development & Partnering
  • Biomarkers & Surrogate Endpoints for Clinical Trials
  • Big Data Analytics for Biomarkers Development

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