Biochemical Pathways of Allergy

Analysis of genetically engineered mice and biochemical studies continue to help unravel the molecular pathways that drive allergic inflammatory reactions. The knowledge acquired may lead to novel approaches for suppressing allergic inflammation.

Allergic reactions might progress in two distinct phases: an early response, which is characterized by mast cell degranulation and release of inflammatory mediators as a consequence of IgE antibodies cross-linked to their high-affinity receptors (FcεRI) expressed on mast cells membranes, and a late phase response, characterized by a T-helper type 2 (Th2) response, with an increased secretion of cytokines such as IL-4 and IL-13, which stimulate B cells to synthesize IgE; IL-5, necessary for eosinophilic inflammation; IL-9, which stimulates mast cell proliferation

  • Signaling Pathways Critical for Allergic Airway Inflammation.
  • Effector Mechanisms in Allergic Reactions
  • Effector Mechanisms in Allergic Reactions: Common Diagnostic Pathway & Alternative Diagnostic Pathway
  • Activation & Granulation Mechanism

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