Biomarker: Diagnostic Tool for Diabetes

Biomarkers can be defined  as “a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarkers play an integral part in conducting clinical trials and treating patients. In most instances, they help medical practitioners, researchers, and regulatory officials make well-informed, scientifically sound decisions. More efficient discovery and use of biomarkers in the development of antidiabetes drugs will depend on advancing our understanding of the pathogenesis of diabetes and especially its macrovascular complications.  Methodological advances from other fields, especially oncology, are beginning to pave the way toward improved models of diabetes pathogenesis and biomarker discovery.

 

Biomarkers are conventionally defined as “biological molecules that represent health and disease states.” They typically are measured in readily available body fluids, lie outside the causal pathway, are able to detect subclinical disease, and are used to monitor clinical and subclinical disease burden and response to treatments.Diabetes mellitus is a complex disease affecting almost every tissue and organ system, with metabolic ramifications extending far beyond impaired glucose metabolism. Biomarkers may reflect the presence and severity of hyperglycemia or the presence and severity of the vascular complications of diabetes.

  • Prognostic marker
  • Diabetic nephropathy marker
  • Molecular markers for both metabolic syndrome and hypoglycemia response
  • Genetic lifestyle interaction in the development and prevention of diabetes

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Biomarker: Diagnostic Tool for Diabetes Conference Speakers