Biomarkers in Translational Medicine

Translational medicine is the emerging discipline involving the translation of laboratory findings into the design and implementation of early-stage clinical trials.TM focuses on translating pre-clinical data from in vivo, in vitro, and in silicon research into the clinic to help design trials, determine methods and choose the biomarkers. Biomarkers play a vital role in the development and growth of translational medicine. Predictive biomarkers are the markers which can be used to identify subpopulations of patients who are most likely to respond to a given therapy.

Biomarkers in clinical drug development enable continued clinical development of drugs suspected of human irrelevant animal toxicities– ensuring patient safety, reducing drug failures and loss of time. A genomic biomarker is a measurable DNA or RNA characteristic that is an indicator of normal biologic processes, pathology diagnosis and response to therapeutic or other interventions. Ex: Cancer Biomarker Specific and sensitive mRNA biomarkers are used for the identification of skin in ‘touch DNA’ evidence.

Traditionally, oncology has been at the forefront of the biomarker development and PM. However, as technologies advance, fields such as neuroscience and immunological, inflammatory, and metabolic diseases are expanding their use of biomarkers for PM. Translational medicine seeks to identify individuals who will receive the most clinical benefit and least harm from a specific treatment by targeting genetic or other targets associated with their disease. Enabled by technological advances and expansion of the use of biomarkers, researchers can stratify patients into disease subtypes and evaluate targeted therapies aimed at treating them.

Translational medicine is the emerging discipline involving the translation of laboratory findings into the design and implementation of early-stage clinical trials.TM focuses on translating pre-clinical data from in vivo, in vitro, and in silicon research into the clinic to help design trials, determine methods and choose the biomarkers. Biomarkers play a vital role in the development and growth of translational medicine. Predictive biomarkers are the markers which can be used to identify subpopulations of patients who are most likely to respond to a given therapy.

  • Biomarker discovery
  • Clinical validation of predictive biomarkers
  • Role of biomarkers in clinical drug development
  • Integrating genomic biomarkers into clinical development
  • mRNA biomarkers

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