Biomarkers in Translational Medicine

Translational medicine is the emerging discipline involving the translation of laboratory findings into the design and implementation of early-stage clinical trials.TM focuses on translating pre-clinical data from in vivo, in vitro, and in silicon research into the clinic to help design trials, determine methods and choose the biomarkers. Biomarkers play a vital role in the development and growth of translational medicine. Predictive biomarkers are the markers which can be used to identify subpopulations of patients who are most likely to respond to a given therapy.

Biomarkers in clinical drug development enable continued clinical development of drugs suspected of human irrelevant animal toxicities– ensuring patient safety, reducing drug failures and loss of time. A genomic biomarker is a measurable DNA or RNA characteristic that is an indicator of normal biologic processes, pathology diagnosis and response to therapeutic or other interventions. Ex: Cancer Biomarker Specific and sensitive mRNA biomarkers are used for the identification of skin in ‘touch DNA’ evidence.

  • Biomarker discovery
  • Clinical validation of predictive biomarkers
  • Role of biomarkers in clinical drug development
  • Integrating genomic biomarkers into clinical development
  • mRNA biomarkers

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