Biopharmaceutics: Drug Discovery and Development

\r\n The field of new drug development has moved its focus from small-molecule compounds to large-molecule proteins and other biopharmaceuticals. These biopharmaceuticals have caused an archetype shift in disease cure and has led to an enhancement in the quality of life of patients with various diseases such as autoimmune diseases, refractory cancers  biopharmaceuticals represent 7.5% of all drugs in the market and account for ~10% of the total expenses for marketed drugs. The usage of biopharmaceuticals are increasing at the rate >20% per year. They are already being used74% more than chemically derived pharmaceuticals, in life-saving or end-stage applications. Moreover, biopharmaceuticals covers > 30% of all pipeline research programs going-on at present which embraces all recombinant proteins, monoclonal antibodies, cytokines, peptides, vaccines, blood/plasma-derived products, non-recombinant culture-derived proteins, nucleic acid-based products (DNA, RNA or antisense oligonucleotides used for curative or in vivo diagnostic purposes), cells and tissues cultures. This view is possibly best understood by the public and mostly used by the people in the biopharmaceutical industry.


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