Biopolymers for Tissue Engineering and Regenerative Medicine

Tissue engineering has been an area of immense research in recent years because of its vast potential in the repair or replacement of damaged tissues and organs. The present review will focus on scaffolds as they are one of the three most important factors, including seed cells, growth factors, and scaffolds in tissue engineering. Among the polymers used in tissue engineering, poly(-hydroxy esters) (such as PLA, PGA, and PLGA) have attracted extensive attention for a variety of biomedical applications. Besides, PCL has been widely utilized as a tissue engineering scaffold. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA.  The global market for tissue engineering and regeneration products reached $55.9 billion in 2010, is expected to reach $59.8 billion by 2013, and will further grow to $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%.

BioPolymers have been widely used as biomaterials for the fabrication of medical device and tissue-engineering scaffolds. Polymeric scaffolds are drawing a great attention due to their unique properties such as high surface-to-volume ratio, high porosity with very small pore size, biodegradation, and mechanical property. They offer distinct advantages of biocompatibility, versatility of chemistry, and the biological properties which are significant in the application of tissue engineering and organ substitution. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated.

  • Tissue engineering and Regenerative medicine
  • Whole organ engineering and approaches
  • Bone and cartilage tissue engineering
  • Scaffolds
  • Novel approaches in guided tissue regeneration
  • Biopolymer methods in Cancer therapy

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