Cancer And The Immune System

In most organs and tissues of a mature animal, a balance is maintained between cell renewal and cell death. The various types of mature cells in the body have a given life span; as these cells die, new cells are generated by the proliferation and differentiation of various types of stem cells. This cell growth and proliferation are essential for wound healing and homeostasis. Under normal circumstances in the adult, the production of new cells is regulated so that the number of any particular type of cell remains fairly constant. Occasionally, however, cells arise that no longer respond to normal growth control mechanisms; these cells proliferate in an unregulated manner, giving rise to cancer

  • Malignant transformation of cells
  • DNA alterations
  • Tumor antigens
  • Immunologic pathway involving tumor eradication
  • Cancer immunoediting

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