Cancer Genetics

Cancer is a Genetic disease caused mainly due to the Alterations in different kinds of Genes. A change in a gene is called a ‘fault’ or ‘mutation’. All cancers develop because something has gone wrong with one or more of the genes in a cell. Cancer Genetics is the branch of Genetics dealing with gene alterations in Cancer patients. Mutations in Oncogenes and Tumor suppressor genes contribute to the development of cancer. The most commonly mutated gene in people who have cancer is p53. Genetic changes that increase cancer risk can be inherited from our parents if the changes are present in germ cells, which are the reproductive cells of the body (eggs and sperm). Such changes, called Germ line changes, are found in every cell of the offspring. Germ line mutations in BRCA1 or BRCA2 genes increase a women’s risk of developing Hereditary Breast Cancer or Ovarian Cancers. Mutations in tumor suppressor gene of PTEN protein causes Cowden Syndrome, an inherited disorder that increases the risk of Breast, Thyroid, Endometrial and other types of cancer.

  • Oncogenes
  • Proto-Oncogenes
  • Tumour Suppressor genes
  • DNA Repair Genes
  • Toxicology and Cancer
  • Cancer Genomics
  • Cancer Genome Sequencing

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Cancer Genetics Conference Speakers

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