Cancer Metabolism

Tumors reprogram nutrient acquisition and metabolism pathways to meet the demands of malignant cells that are bioenergetic, biosynthetic, and redox. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. From this viewpoint, we provide a theoretical framework for understanding how and why metabolic reprogramming takes place in tumor cells, and the mechanisms that link altered metabolism to tumorigenesis and metastasis. Learning these principles will slowly support the development of new human cancer treatment approaches.

 

 

  • Mitochondria
  • Glycolysis
  • Oncogenes
  • Chromosomal Translocation
  • Hypoxia

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