Carcinogenesis and Mutagenesis

Carcinogenesis is also called as Tumorigenesis or Oncogenesis. It is the formation of cancer where the normal cells are transformed into the Cancer cells. The process is characterized by changes in the abnormal cell division, cellular, genetic, and epigenetic levels. Cell division is a physiological procedure that occurs in all tissues. Normally the balance between proliferation and automatic cell death, in the form of Apoptosis, is maintained to ensure the consistency of tissues and organs.

Mutagenesis is a method by which the genetic information of an organism is altered, resulting in a mutation. DNA may be altered either naturally or artificially by using physical, chemical and biological agents which results in mutations. Mutagen generally changes the genetic material of DNA of an organism and increases the occurrence of mutation and increased level of Mutations cause Cancer. Some of the chemicals become mutagenic only through cellular processes and all the mutations are not caused by mutagens: “Spontaneous Mutations” occur due to hydrolysis, errors in DNA replication, repair and recombination.

  • Oncogenes
  • Proto-oncogenes
  • Tumor suppressor genes
  • Multiple mutations
  • Non-mutagenic carcinogens

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Carcinogenesis and Mutagenesis Conference Speakers

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