Causes of COPD

COPD is a disease that involves inflammation and thickening of the airways. It also involves destruction of the tissue of the lung where oxygen is exchanged. It is described by the Global Initiative for Chronic Obstructive Lung Disease as “a preventable and treatable disease…characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases. This progressive and relentless loss of lung function is caused by emphysema due to destruction of lung parenchyma. Smoking(long term smokers), Chronic bronchitis, Inherited factors(genes) and by narrowing of small airways as a result of chronic inflammation and fibrosis and loss of elastic recoil. This results in progressive airflow limitation, air trapping, and progressive shortness of breath on exertion.

In the vast majority of cases, the lung damage that leads to COPD is caused by long-term cigarette smoking. But there are likely other factors at play in the development of COPD, such as a genetic susceptibility to the disease, because only about 25 percent of smokers develop COPD. Alpha-1-antitrypsin (AAt) is made in the liver and secreted into the bloodstream to help protect the lungs. Alpha-1-antitrypsin deficiency can affect the liver as well as the lungs.

  • Asthma
  • Bullous Emphysema
  • Smoking(Long Term Smokers)
  • Chronic Bronchitis
  • Inherited Factors(Genes)

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