Cell and Organ generation

Evolving evidence suggests that bone marrow-derived endothelial, hematopoietic stem and progenitor cells contribute to tissue vascularization during both embryonic and physiological processes. Recent preclinical and pioneering clinical studies have shown that introduction of bone marrow-derived endothelial and hematopoietic progenitors can restore tissue vascularization after ischemic events in limbs, retina, and myocardium. Co conscription of an incompetent hematopoietic cells delivering specific angiogenic factors enables the combination of endothelial progenitor cells (EPCs) into newly sprouting blood vessels. Identification of cellular mediators and tissue-specific chemokines, which facilitate selective recruitment of bone marrow-derived stem and progenitor cells to specific organs will open up new avenues of research to accelerate organ vascularization and regeneration. As well, identification of factors that promote differentiation of the progenitor cells will permit functional incorporation into neo-vessels of specific tissues while diminishing potential toxicity to other organs. In this review, we deliberate the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function.

  • traumatic brain injury
  • Alzheimer’s disease
  • Muscular dystrophy
  • Osteoarthritis rheumatoid arthritis
  • Skin avulsion
  • Neuro Regeneration
  • Liver Regeneration
  • Bone Regeneration

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