Cell Mediated Immunity

Cell-mediated immunity is an immune response that does not involve antibodies, but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Historically, the immune system was separated into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells. CD4 cells or helper T cells provide protection against different pathogens. Cytotoxic T cells cause death by apoptosis without using cytokines, therefore in cell-mediated immunity cytokines are not always present.

The two branches of immunity includes, humoral immunity and cell-mediated immunity. The humoral immune response,  is the aspect of immunity that is mediated by secreted antibodies  produced in the cells of the B lymphocyte lineage (B cell). The humoral immunity deals with the interaction of B cells with antigen and their subsequent proliferation and differentiation into antibody secreting plasma cells. Antibody functions as the effector of the humoral response by binding to antigen and neutralizing it or causing its elimination.

  • Humoral Immunity
  • Recognition of foreign Antigens by T-cells
  • Recognition of foreign bodies by B-cells

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