Challenges in Pediatric Drug Development

There are lots of diseases in children for which proper drugs are not available. These unmet medical issues are more so because large no. of drugs is not approved for children yet prescribed to them. It has been a real challenge for more than five decades. The important aspect of child care is to understand the stages of growth and development. Most important among all organ system is the central nervous system. Focusing on all subtle changes in this vulnerable phase is highly crucial. Drugs should be formulated keeping all aspects in mind. Starting from infancy till late adolescence, the phase observes a lot of changes. Moreover, animal models do not provide the perfect platform to approve any drug formulation. So, the need to scrutinize each step is very necessary. Yet a ray of hope has been found with concurrent success regarding hepatic pharmacology, pharmacogenomics and population pharmacokinetics which have provided genuine data for absorption, distribution, metabolism, and elimination status of some pediatric drugs.

There are lots of diseases in children for which proper drugs are not available. These unmet medical issues are more so because large no. of drugs is not approved for children yet prescribed to them. It has been a real challenge for more than five decades. The important aspect of child care is to understand the stages of growth and development. Most important among all organ system is the central nervous system. Focusing on all subtle changes in this vulnerable phase is highly crucial. Drugs should be formulated keeping all aspects in mind. Starting from infancy till late adolescence, the phase observes a lot of changes. Moreover, animal models do not provide the perfect platform to approve any drug formulation. So, the need to scrutinize each step is very necessary. Yet a ray of hope has been found with concurrent success regarding hepatic pharmacology, pharmacogenomics and population pharmacokinetics which have provided genuine data for absorption, distribution, metabolism, and elimination status of some pediatric drugs.

  • Past, Present, and Future of Pediatric Drug Development
  • Ethical Concerns Related to Pediatric Drug Development
  • Pharmacological Policies in Pediatric Drug Development
  • Clinical Trials in Pediatric Drug Development.
  • Formulation, Chemistry, and Safety Endpoints

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