Chemotherapeutic Agents

Over the past decade, there has been a paradigm shift in the treatment of cancer, driven by advances in personalized medicine and immuno-oncology. According to the WHO, cancer was the second leading cause of death in 2015, responsible for 8.8 million deaths globally. From 2011-2015, 42 new cancer medicines were launched globally, but the availability of newly launched agents differs substantially by geography, with the highest number of novel agents being available in the United States and Germany. The pipeline of oncology drugs in clinical development has expanded by 45% over the past ten years. Oncology research and development activity remains concentrated on targeted therapies, which made up 90% of the late phase pipeline in 2016. Focus is being placed on targeted therapies that use genetic marker tests to indicate a greater likelihood of tumour response, or amplify the patient’s own immune response to target the cancer. The late phase oncology pipeline includes 278 biologic therapies, including 15 gene therapies, 133 new monoclonal antibodies (mAbs), and 14 biosimilars of existing mAbs. The late phase pipeline also includes 82 potential vaccines for a wide variety of tumour types. Immunotherapies are one of the fastest growing areas within oncology R&D, and will undoubtedly make up a larger portion of the pipeline in 2021.

  • Alkylating Agents
  • Anthracyclines
  • Cytoskeletal Disruptors (Taxanes)
  • Epothilones
  • Histone Deacetylase Inhibitors
  • Inhibitors of Topoisomerase I
  • Inhibitors of Topoisomerase II
  • Kinase Inhibitors
  • Nucleotide Analogs & Precursor Analogs
  • Peptide Antibiotics
  • Platinum-based Agents
  • Retinoids
  • Vinca Alkaloids & Derivatives

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Chemotherapeutic Agents Conference Speakers

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