Clinical and Translational Oncology

Cancer remains the number two cause of disease-related mortality in the United States and worldwide. The molecular analysis of tumors has revealed significant variation in the pathways that drive tumor growth and metastasis. Translational Oncology is concerned with the diagnosis of cancer (pathology), Therapy (e.g. surgery, chemotherapy, radiotherapy and other modalities), Follow-up of cancer patients after successful treatment, Palliative care of patients with terminal malignancies. Oncology depends on diagnostic tools like biopsy or removal of bits of the tumor tissue and examining it under the microscope. Other diagnostic tools include endoscopy for the gastrointestinal tract, imaging studies like X-rays, CT scanning, MRI scanning, ultrasound and other radiological techniques, Scintigraphy, Single Photon Emission Computed Tomography, Positron emission tomography and nuclear medicine techniques etc.

Cancer is a genetic disease caused by the progressive accumulation of mutations in critical genes that control cell growth and cell differentiation. Completion of the Human Genome Project promises to revolutionize the practice of Medicine, especially genetic oncology care. The tremendous gains in the knowledge of the structure and function of human genes will surely impact the diagnosis, prognosis and treatment of cancer. Translational research also describes the process of moving knowledge obtained from clinical trials into a wider community or practice setting.

Many articles have reinforced what cancer clinicians know very well; progress in the treatment of the most common forms of cancer has been frustratingly slow yielding modest improvement in survival rates. In contrast, spectacular advancements have been made in basic research to characterize and understand the fundamental molecular underpinnings that drive cancer. Targeted therapy is now the dominant approach in cancer therapeutics, driving the majority of new cancer drugs being developed in both academic and commercial biotechnology.

Cancer remains the number two cause of disease-related mortality in the United States and worldwide. The molecular analysis of tumors has revealed significant variation in the pathways that drive tumor growth and metastasis. Translational Oncology is concerned with the diagnosis of cancer (pathology), Therapy (e.g. surgery, chemotherapy, radiotherapy and other modalities), Follow-up of cancer patients after successful treatment, Palliative care of patients with terminal malignancies.

 

  • Clinical trails translational
  • Clinical trails translational
  • Drug discovery and development
  • Cellular and genetic oncology
  • Laboratory concepts from bench to beside
  • Cancer microenvironment
  • Translational Cancer Research

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