Clinical Studies & Case Reports
A medical case report is generally considered a type of anecdotal evidence. Given their intrinsic methodological limitations, including lack of statistical sampling, case reports are placed at the foot of the hierarchy of clinical evidence, together with case series for the clinical reviews. Nevertheless, case reports do have genuinely useful roles in medical research and evidence-based medicine. In particular, they have facilitated recognition of new diseases like Thyroid, Pregnancy and adverse effects of treatments. Case reports have role diseases. They can also help understand the clinical spectrum of rare diseases, as well as unusual presentations of common diseases. They can help generate study hypotheses, including plausible mechanisms. Case reports may also have a role to play in guiding the personalization of disorders and treatments in clinical practice.
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