Cushing Disease

Overproduction of a pituitary gland hormone leads to an overactive adrenal gland. A similar condition called Cushing's syndrome may occur in people, particularly children, who take high doses of corticosteroid medications. It is a cause of Cushing's syndrome characterized by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary. This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids.

Cushings disease is a pituitary gland disorder which is due to the over production of hormones in the pituitary gland that results in the hyperactive adrenal gland. This is due to the over production of adrenocorticotropic hormone (ACTH) that is produced by anterior part of pituitary gland. This plays a major role in the production of pituitary adenoma which is 80% responsible for the resulting of cushing syndrome. The most common signs of the cushing disease can be used to detect cushing syndrome which includes weight gain , high blood pressure , post short term memory, moon shaped face, menstural periods at irregular intervals, excess fat around the neck region, over hair growth in woman, improper functioning of immunological system, fatigue of body parts, these symptoms are on the first line to detect cushing disease.

  • Signs and Symptoms
  • Diagonosis and treatment
  • Treatment
  • Epidemology
  • Hyperplasia
  • Dexamethasone suppression test
  • Brain MRI and lipid and cholesterol testing
  • Inferior petrosal sinus sampling
  • Pseudo-cushing states
  • Hyperaldosteronism
  • Hypoaldosteronism
  • Pheochromocytoma/paraganglioma
  • Case studies
  • Symptoms, diagnosis & treatment
  • Hypoaldosteronism and hyperaldosteronism

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