Developments in COPD Management

The aim of the present study is to manage the impact of COPD on health status by Characterization of human lung tissues by advanced molecular, biochemical, microbiological, and histo pathological methods. A better understanding of the cellular and molecular mechanisms that are involved in the underlying inflammatory and destructive processes has revealed several new targets for which drugs are now in development, and the prospects for finding new treatments are good. Research progress in COPD is hampered by a lack of fundamental knowledge regarding the pathology of this disease, particularly with regard to small airways. Changes with COPD in the structure, cellular composition, inflammatory status, and chemical milieu of the lung are poorly defined, as are the relationships of these changes to clinical manifestations of the disease. Characterization of lung tissues can now be performed with exquisite detail, using advanced methods of immunology. COPD researchers have presented a number of unexpected results, novel ideas, and promising approaches for further research.

There is a major need to develop new treatments for chronic obstructive pulmonary disease (COPD), as no currently available drug therapy reduces the relentless progression of the disease. In particular, there is a need to develop drugs that control the underlying inflammatory and destructive processes. COPD involves a chronic inflammation in the small airways and lung parenchyma with the involvement of neutrophils, macrophages, and cytotoxic (CD8+) T lymphocytes. This inflammation results in fibrosis with narrowing of the small airways (chronic obstructive bronchitis) and lung parenchymal destruction due to the action of various proteases such as neutrophil elastase and matrix metallo proteinases (emphysema).

  • Pharmacologic Treatment
  • Non pharmacologic Treatment
  • Asthma Management

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