Diabetes for Gene Therapy

Cell therapy approaches for this disease are focused on developing the most efficient methods for the isolation of pancreas beta cells or appropriate stem cells, appropriate location for cell transplant, and improvement of their survival upon infusion. Alternatively, gene and cell therapy scientists are developing methods to reprogram some of the other cells of the pancreas to secrete insulin. Currently ongoing clinical trials using these gene and cell therapy strategies hold promise for improved treatments of type I diabetes in the future. The first gene therapy approach to diabetes was put forward shortly after the cloning of the insulin gene. It was proposed that non-insulin producing cells could be made into insulin-producing cells using a suitable promoter and insulin gene construct, and that these substitute cells could restore insulin production in type 1 and some type 2 diabetics. 

Related Conferences: International Conference on Synthetic Biology, September 28-30, 2015 (Houston, USA); 6th World Congress on Biotechnology, October 05-07, 2015 (New Delhi, India); 3rd International Conference on Genomics & Pharmacogenomics, September 21-23, 2015 (San Antonio, USA); World Bio Summit & Expo, November 02-04, 2015 (Dubai, UAE); International Conference on Genetic Counselling And Genomic Medicine, August 11-12, 2016 (Birmingham, UK); Cell Symposia: Stem Cell Epigenetics 20-22 September 2015 (Barcelona, Spain); EMBO Conference The DNA damage response in cell physiology and disease 5-9 October 2015 (Cape Sounio, Greece); EMBO Conference Nuclear structure and dynamics 7-11 October 2015 (L'Isle-sur-la-Sorgue, France); CSH Asia Mitochondria 12-16 October 2015 (Cold Spring Harbour, New York); ABCAM Chromatin Structure and Function 16-19 November 2015 (Grand Cayman Island).

Living well with diabetes requires a lifelong commitment to monitoring blood sugar, eating properly, exercising regularly and maintaining a healthy weight. People with type 1 diabetes must also rely on insulin replacement therapy, usually through insulin injections. Gene therapy will be considered as including any approach that involves the introduction of a foreign gene into any cell type in the body, allowing it to produce insulin. The gene(s) introduced could be the insulin gene itself, perhaps under control of a tissue-specific promoter, allowing for expression in a select non–β-cell type, or a gene encoding a factor that in turn activates the insulin gene, thereby allowing for ectopic insulin production.

  • Restoration of insulin secretions
  • Islet transplantation
  • Experimental gene therapy
  • Beta cell replacement strategies
  • Use of stem cells in diabetes gene therapy

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Diabetes for Gene Therapy Conference Speakers