Diagnosis of Parkinson Disease

Making an accurate diagnosis of Parkinson’s particularly in its early stages — is difficult. The use of functional neuroimaging in neurodegenerative diseases has increased in recent years, with applications in research in the underlying pathophysiology, aiding in diagnosis, or evaluating new treatments. In Parkinson's disease (PD), these imaging ways have expanded our understanding of the disease on the far side dopaminergic deficits area unit of diagnostics and Neuroimaging for Parkinson disease are Clinical pathological and genetic overlap in parkinsonism, Detecting prodromal Parkinson’s disease, Nuclear imaging to study Laboratory investigations supporting the diagnosis of MSA, PSP and CBD, Utility of next generation sequencing in the diagnosis of parkinsonian disorders, Clinic-genetic correlations in parkinsonian disorders, Therapeutic strategies in genetic forms of proteinopathies,  pathophysiology to new treatment strategies Insights from the laboratory and Disease-modifying, animal models and Symptomatic treatments, Update on surgical and medical treatment of the dystonia’s, Instrumental analysis of tremor, Instrumental analysis of parkinsonian symptoms, analysis of gait and postural reflexes, Neuroprotective treatments and Complementary Therapy.

Accurate diagnosis of Parkinson Disease, and other forms of parkinsonism, and ET can be a challenge. The most common differential diagnoses include essential tremor (ET); atypical parkinsonism such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), diffuse Lewy body (DLB) disease, and corticobasal degeneration (CBD); Alzheimer disease; and vascular, drug-induced, and psychogenic parkinsonism. In a study of 100 patients clinically diagnosed with Parkinson Disease by a general neurologist, autopsy findings revealed a diagnostic accuracy of 76%. In another study of patients diagnosed with parkinsonism in the community, 15% were misdiagnosed with PD and 19% had PD but were diagnosed with another disorder. The majority of those misdiagnoses were ET. The autopsy is the only way to definitively diagnose PD The correct diagnosis depends largely on the expertise of the physician and a good clinical history. In difficult cases, neuroimaging may serve as a tool to improve diagnostic accuracy, particularly between PD and ET.

  • Instrumental analysis of tremor
  • Instrumental analysis of parkinsonian symptoms
  • Complementary Therapy
  • Neuroprotective treatments
  • Analysis of gait and postural reflexes
  • Detecting prodromal Parkinsons disease
  • Clinical pathological and genetic overlap in parkinsonism
  • Nuclear imaging to study parkinsonian disorders
  • Disease modifying and symptomatic treatments
  • Myoclonus, Etiology, pathophysiology and treatment
  • Clinico-genetic correlations in parkinsonian disorders
  • Therapetuic strategies in genetic forms of proteinopathies
  • Update on medical and surgical treatment of the dystonias
  • Laboratory investigations supporting the diagnosis of MSA and PSP/CBD
  • Utility of next generation sequencing in the diagnosis of parkinsonian disorders
  • Pathophysiology to new treatment strategies: Insights from the laboratory and animal models
  • Huntington’s disease: From natural history studies to experimental therapeutics

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