Diagnostic Pathology of Infectious Disease

Clinical approach is the method where biopsy is used for diagnosis of an infection. Virtually every woman is affected by a gynecological condition or infection at some time during her life. Chlamydia, a sexually transmitted vaginal infection, is the most frequently reported infectious disease in the U.S. However, 75 percent of women have no symptoms and may not seek health care. Left untreated, 40 percent of women will develop PID and many of these women will become infertile. Group B streptococci (GBS) emerged dramatically in the 1970s as the leading cause of neonatal infection and as an important cause of maternal uterine infection. We review the epidemiology, diagnosis, and therapy of GBS perinatal infection. In 1996, the first national consensus guidelines were released. Since then, there has been a 70% reduction in early-onset neonatal GBS infection, but no decrease in late-onset neonatal GBS disease. In 2002, new national guidelines were released recommending 1) solely a screen-based prevention strategy, 2) a new algorithm for patients with penicillin allergy, and 3) more specific practices in certain clinical scenarios. Yet many clinical issues remain, including implementation of new diagnostic techniques, management of preterm rupture of membranes, use of alternative antibiotic approaches, improvement of compliance, prevention of low birth weight infants, emergence of resistant organisms, and vaccine development.
  • Biopsy in the diagnosis of infection: Clinical approach
  • Ultrastructural diagnosis of infection
  • Pulmonary, gastrointestinal and cardiac infections
  • Infectious lymphadenitis
  • Gynecologic and perinatal infections

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