DNA Damage and Repair

DNA Damage and DNA Repair both terms are related with the maintenance of genome integrity. DNA Damage may lead to mutation and finally causing many serious diseases. The biochemical mechanisms of these pathways have been characterized and the impact of this work was recently highlighted by the selection of Tomas Lindahl, Aziz Sancar and Paul Modrich as the recipients of the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways. Currently University of Alabama, UNC School of Medicine, Emory University School of Medicine and Newcastle University are working on this field.

  • DNA mutation & deamination
  • Chemical modification of bases
  • Strand breaks
  • Medicine and DNA repair modulation
  • DNA repair and cancer

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