Downstream Bioprocessing

The downstream part of a bioprocess refers to the part where the cell mass from the upstream are processed to meet purity and quality requirements. Downstream processing is usually divided into three main sections: Cell disruption, a purification section and a polishing section. Downstream research involves Vaccine development and production, Formulation and downstream processing, Cell disruption and cell debris removal in downstream bioprocessing, Disposable bioprocessing system, and Downstream Single-use technologies. 250 more institutes are conducting research on downstream bioprocessing. 194 universities are offering downstream processing in USA. More than 500 universities offering from other part of the world. 10, 000, 00 $ funds are released in USA for year 2014. In other part of the world $ 1 crore were released in 2014. There are 25000 more industries working on Downstream Bioprocessing.

The downstream part of a bioprocess refers to the part where the cell mass from the upstream are processed to meet purity and quality requirements. Downstream processing is usually divided into three main sections: Cell disruption, a purification section and a polishing section. The volatile products can be separated by distillation of the harvested culture without pre-treatment. Distillation is done at reduced pressure at continuous stills. At reduced pressure distillation of product directly from fermenter may be possible.

Downstream Bioprocessing includes Vaccine development and production, Formulation and downstream processing, Cell disruption and cell debris removal in downstream bioprocessing, Disposable bioprocessing system, Downstream Single-use technologies.

  • Vaccine development and production
  • Formulation and downstream processing
  • Cell disruption and cell debris removal in downstream bioprocessing
  • Disposable bioprocessing system
  • Downstream Single-use technologies

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