Drug Designing & Therapy

The phrase "drug design" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for envision of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and effective  drug. These other characteristics are often difficult to predict with rational design techniques. Still, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are anticipated to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Moreover, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.

The phrase "drug design" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for envision of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and effective  drug. These other characteristics are often difficult to predict with rational design techniques. Still, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are anticipated to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Moreover, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.

  • Receptor-based Drug Design
  • Pharmacophore based Drug Design
  • Structural based drug designing
  • Procedure for Drug Designing
  • Drug Designing Docking&Rational Drug Design
  • Combination Therapy
  • Pharmacophore Therapy

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