Drug Discovery and Novel Delivery Technologies

In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge. The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. These days, drug delivery companies are engaged in the development of multiple platform technologies to get competitive advantage, extend patent life, and increase market share of their products. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.

Drug delivered can have significant effect on its efficacy. Some drugs have an optimum concentration range with in which maximum benefit is derived and concentrations above (or) below the range can be toxic or produce no therapeutic effect. The  main  goal  for  developing  such  delivery  systems is  to  minimize  drug degradation  and  loss,  to  prevent  harmful  side  effects  and  to  increase  bioavailability.  Targeting is the ability to direct the drug loaded system to the site of interest. New drug carriers systems are one can name soluble polymers,   micro particles   made   of   insoluble   (or)   biodegradable   natural   and   synthetic   polymers, microcapsules, cells, cell ghosts, lipoproteins, liposomes and micelles.

  • Policies to stimulate drug development and discovery
  • Role of computational biology
  • Ligand binding studies
  • Transport (simulation studies)
  • Molecule mediating transport

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