Drug Discovery and Therapy

National Cancer Institute (NCI) provides preclinical cancer research, which includes evaluating the preclinical safety and pharmacokinetics of chemotherapeutics and chemopreventive agents. Many research Laboratories also provides genetic toxicology testing for NCI's chemoprevention program, synthesizes compounds for NCI's carcinogen repository, and manufactures clinical trial materials.

National Cancer Institute (NCI) funded for Tumour Glycome Laboratories. They are the principal component of the trans-NIH Alliance of Glycobiologists for Detection of Cancer and Cancer Risk, which is searching for glycan-based biomarkers for breast, ovarian, lung, prostate and pancreatic cancers and melanoma.

More than 30 years of research has led to numerous drugs on the market or ready for licensing, including:

·         Targretin® (bexarotene), a retinoid receptor ligand marketed by Eisai

·         Tirapazamine, a hypoxic tissue-selective cytotoxin

·         TAS-108, a selective estrogen receptor modulator licensed to Taiho Pharmaceutical

·         PDX (pralatrexate), an antimetabolite licensed to Allos Therapeutics

·         SR16157, a dual estrone sulfatase / ER antagonist for breast cancer treatment

The discovery and development of small molecule cancer drugs has been revolutionised over the last decade. Most notably, we have moved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a personalised medicine strategy that focuses on the discovery and development of molecularly targeted drugs that exploit the particular genetic addictions, dependencies and vulnerabilities of cancer cells.

  • Anti-Cancer Drug Discovery and Therapy
  • CVS Drug Discovery and Therapy
  • Innovative Drug Discovery and Nanotechnology
  • Anti-Infectives Drug Discovery and Therapy
  • CNS Drug Discovery and Therapy
  • Anti- Diabetic Drug Discovery and Therapy
  • Application of Nanotechnology in Pharmaceutical Formulation Design and Development

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