Drug Interaction in Infectious Diseases

Drug interactions in infectious diseases are a major source of medical harm that can be prevented. It is notable that drug interactions represent a major risk to patients. Even a casual look at approved drug product labels for anti-infective drugs, such as azole antifungal drugs, direct-acting antivirals for HCV, HIV drugs and anti-mycobacterial agents unveil that drug interactions present a huge challenge for patients and their healthcare providers. Concerns regarding the interaction of drugs rise as the knowledge of pharmacology advances. The interactions may be due to non-CYP enzymes, CYP enzymes, and changes in gastric pH, the ever-growing list of drug transporters and more. Other considerations incorporate interactions due to herbal medications, food components and biological products.

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