Drug Metabolism in Drug Design

The term “Drug metabolism” refers the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.  It is divided into three phases: I). Enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotic II). Modified compounds are then conjugated to polar compounds III). Conjugated xenobiotic may be further processed, before being recognised by efflux transporters and pumped out of cells.

  • Anti-neurodegenerative drug discovery
  • Ion channels, transporters and neurotransmitter receptors
  • Neural stem cells and gene or cell therapy
  • Neurotransmitters, neuromodulators, and neuroreceptors
  • Centrally acting analgesics
  • Blood brain barrier (BBB)
  • Metabolism mediated drug-drug interactions
  • Enzyme kinetics
  • Role of drug metabolism in drug development
  • Nanoparticles as drug carriers
  • Neurological Drug Targets

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