Eicosanoids and Reproduction

Eicosanoids play an important role in reproduction. Firstly they are involved in pregnancy-induced hypertension. Urine of normotensive and hypertensive pregnant women was analyzed which showed reduced PGE2 and 6-keto-PGF1 alpha excretion in preeclamptic subgroup of hypertensive patients during last two trimesters. Further, tissue cultures of human placentas, deciduas and fetal membranes from hypertensive pregnancies displayed reduced prostaglandin production. Secondly, PGE2 of fetal membrane plays key role for beginning or parturition. Thirdly, enhancement of PGF2 alpha and PGE2 formation in secretory endometrial cells participates in endometrial function. There are many more uses of eicosanoids in reproduction. Frontiers never end for the research work in the role of eicosanoids in reproduction.

  • Eicosanoids
  • Pregnancy-induced hypertension
  • Prostaglandin
  • Preeclampsia
  • Placenta
  • Endometrial function

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