Emerging Focus in Diabetes Research

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased concentration of small dense LDL-cholesterol particles.

There are many risk factors for type 2 diabetes such as age, race, pregnancy, stress, certain medications, genetics or family history,  high cholesterol and obesity. However, the single best predictor of type 2 diabetes is overweight or obesity. Almost 90% of people living with type 2 diabetes are overweight or have obesity. People who are overweight or have obesity have added pressure on their body's ability to use insulin to properly control blood sugar levels, and are therefore more likely to develop diabetes. The number of diabetes cases among American adults increased by a third during the 1990s, and additional increases are expected. This rapid increase in the occurrence of diabetes is mostly attributed to the growing prevalence of obesity in the United States.

The Bioinformatics/Computational Biology Service branch will provide basic capabilities to the Joslin Diabetes Center to analyze a wide range of high-throughput data. Housed on-site at the Joslin, the group and associated resources will be available to Joslin investigators and fellows who are either planning high-throughput experiments or need analysis of multi-scale data.

We prospectively followed 51,552 Finnish men and women 25–74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated. The entire spectrum of diabesity, including all of its complications–diabetes, elevated blood sugar, blood pressure, and cholesterol–are simply downstream symptoms that result from problems with diet, lifestyle, and environmental toxins interacting with our unique genetic susceptibilities. Bariatric surgery may be an option for adults with severe obesity. Body mass index (BMI), a measure of height in relation to weight, is used to define levels of obesity. Clinically severe obesity is a BMI > 40 or a BMI > 35 with a serious health problem linked to obesity. Such health problems could be type 2 diabetes, heart disease, or severe sleep apnea (when breathing stops for short periods during sleep).

  • Obesity and diabetes
  • Anti-diabetic Agents
  • Bariatric Surgery & Obesity
  • Diabesity - Methods to control or prevent diabetes in obese people
  • ]New technologies for treating obesity
  • Bioinformatics tools and techniques used in diabetes Research
  • Diabetes and Parkinson disease
  • Epidemiology of diabetes in geriatric population
  • Diabetic dyslipidemia
  • Albuminuria

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