Engineered T-Cell Therapy

Engineered T cells are the result of turning a therapeutic process into a product capable of overcoming checkpoint inhibition, and are the future of adoptive immunotherapy. Cytokine release syndrome,” a storm of molecules generated as the cells fights the cancer. Instead of an antibody, single-chain target domain, he used a human cytokine, IL-13, with a mutation in the sequence that gave high affinity for IL-13 receptor α2. These cells were infused intra cranially, establishing the safety of intracranial administration with some antitumor responses.

Although there is little clinical experience with engineered T cells for cancer therapy, it is notable that clinical trials to date using cells engineered to express suicide molecules have indicated that the approach is safe.

  • CAR Strategies in Solid Tumours
  • Prolongation of T-Cell Response by OX40 CC-Signaling CARS
  • Proffered Paper: A New PD-1-CD28 Chimeric Receptor Overcomes PD1-Mediated Immune Suppression in Adoptive T-Cell Therapy
  • Proffered Paper: In-Vivo Testing of PSMA-Targeted T-Cell Immunotherapy for Prostate Cancer

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