Etiology,Renal Pathology-Immunology

The cause of chronic kidney disease isn't always known. But any condition or disease that damages blood vessels or other structures in the kidneys can lead to kidney disease. The conditions that can damage the kidneys and cause chronic kidney disease include:

Kidney diseases and infections, such as polycystic kidney disease, pyelonephritis, glomerulonephritis, or a kidney problem you were born with.

Having a narrowed or blocked renal artery. A renal artery carries blood to the kidneys.

Long-term use of medicines that can damage the kidneys. Examples include non-steroidal anti-inflammatory drugs (NSAIDs), such as celecoxib and ibuprofen, and certain antibiotics.

The kidneys are often targeted by pathogenic immune responses against renal auto antigens or by local manifestations of systemic autoimmunity. For the diagnosis renal pathologists use special tests and electron microscopes to detect the cells involved in diseases affecting the kidneys.

Kidney biopsies permit us to analyze renal disorders; survey anticipations; help in the determination of a particular restorative approach; and screen ailment movement in both local and allograft transplant kidneys. To maximally abuse renal biopsy examples, a blend of light, immunofluorescence and electron microscopy is used. Every type of microscopy requires distinctive strategies for obsession and preparing, so each renal biopsy center section is commonly separated into three sections. Contingent upon the length of the biopsy center or suspected illness process; in any case, the strategy for partitioning the biopsy center might be altered.

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