Flow Chemistry (Pharmaceutical Chemistry)

Scale-up of any pharmaceutical producing method entails a adept combination of art expertise, science and engineering. Combination of many well-established tools like statistical methods (such as style of Experiments (DOE)), PAT method watching tools, and quantitative modelling tools (such as CFD, DEM, PBE, etc.) could give some blessings over the normal ways of method scale-up within the pharmaceutical sector. Advancement during this direction might facilitate to cause a paradigm shift from “Quality by Testing” to “Rational method Design” inside the spirit of the QbD initiative. Some open queries embody however don't seem to be restricted to: however varied tools said, if used separately, will be applied to or sustained for development process scale-up; however the pharmaceutical sector ought to develop a additional innovative use of the present tools. during this session, we tend to ask for papers that facilitate to answer these 2 queries. Papers that specialise in the employment of quantitative tools (e.g. DOE, PAT, modelling, and theory) toward scaling-up pharmaceutical processes in pharmaceutical formulations and linking to QbD implementation within the pharmaceutical sector area unit significantly inspired. The session can give a forum for open exchange of concepts or innovative use of tools for self-made scale-up of the pharmaceutical processes. Papers regarding all areas of pharmaceutical scale-up, from small molecules to biologics, from drug substances to drug products, are being considered.

Flow chemistry production methodology has recently been gaining interest in pharmaceutical R&D. The desire to develop new and improved chemical processes that optimize the use of resources has facilitated a large amount of work in the development of continuous flow reactor technologies. The use of modern continuous flow reactor technologies can deliver a number of distinct advantages over a more traditional batch process. They allow for rapid analysis, optimization and scale-up of a chemical reaction. This ultimately leads to reduced cycle time, increased quality and increased yield.

  • Optimization of Synthetic Routes-Yield Improvement
  • Various Opportunities in Synthetic route Selection
  • Modern Investigative approaches and streamlining the process
  • Environmental Factor (E-factor) and Process Mass Intensity (PMI)
  • Various Synthetic Case Studies Reports
  • Computational Modeling of Multiphase Reactors.
  • Flow Chemistry

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