Future Scope of Cell and Structural Biology

The emergence of the new fields of structural genomics and functional genomics presents us with an unprecedented availability of new macromolecules with so far unknown functions and the promise of novel insights into the mode of action of intact organisms. Technical advances made over several decades have enabled researchers to determine the structures of increasingly larger molecules and complexes, including the protein-making ribosome—a molecular behemoth composed of several RNA molecules and dozens of proteins and the target of many antibiotics. Today, scientists are using high-throughput methods to determine protein structures more quickly than ever before. They are also using computational techniques to predict three-dimensional structures of proteins of unknown structure and to design new proteins with useful functions. This work will continue to increase our understanding of the diverse roles molecules play in biology and to spur advances in medicine. We envision the cell as a little universe in which a multitude of molecular processes occur, recapitulating most of the basic processes of life. The cell functions as an operation center, which integrates all the possible “omics” (genomics, epigenomics, transcriptomics, proteomics, metabolomics, glycomics, exposomics, etc.) to generate context-dependent responses that allow cells to adapt and relate to their surrounding milieu. Owing to the central role of the cell, the tremendous technological progress and the development in systems biology, we are now well positioned to study cell biology and genetics as a whole and translate the enormous potential of these findings to all the possible settings.

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