Gene Expression and Epigenetics
Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation. Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein.
Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Histone, DNA modifying enzymes and chromatin remodelling factors are major area to concentrate.
2nd International Conference on Transcriptomics, September 12-14, 2016 Philadelphia USA; 6th International Conference on Genomics & Pharmacogenomics, September 12-14, 2016 Berlin, Germany; International Conference on Amino Acids and Proteins, December 08-09, 2016 Dallas, USA; International Conference on Biochemistry, October 13-15, 2016 Kuala Lumpur, Malaysia; International Conference on Molecular Genetics, November 28-30, 2016 Chicago, USA; Gordon Research Conference on Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland; Keystone Symposia on Chromatin and Epigenetics (C2), March 20-24, 2016 Whistler, Canada; 18th International Conference on Epigenetics, Chromatin and Transcription, January 07-08, 2016 Singapore; 2nd Epigenomics & Novel Therapeutic Targets, May 26-27, 2016 Boston, USA; 2016
Epigenetics is defined as heritable changes in gene activity and expression that occur without alteration in DNA sequence. It is known these non-genetic alternations are tightly regulated by two major epigenetic modifications: chemical modifications to the cytosine residues of DNA (DNA methylation) and histone proteins associated with DNA. Histone, DNA modifying enzymes and chromatin remodelling factors are major area to concentrate. Different variation in structure leads to Repressive chromatin which can be analysed through Chromatin re-modelling during transcription.
- Structural or dynamic features of chromatin.
- Histone, DNA modifying enzymes and chromatin remodelling factors.
- Gene expression and regulation
- Single cell approaches and modelling
- Repressive chromatin
- Chromatin re-modelling during transcription
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