Genetically Inherited diseases

A genetic disease is any disease that is caused by an abnormality in an individual's genome, the person's entire genetic makeup. The abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosome abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. Most genetic diseases are the direct result of a mutation in one gene. However, one of the most difficult problems ahead is to find out how genes contribute to diseases that have a complex pattern of inheritance, such as in the cases of diabetes, asthma, cancer and mental illness. In all these cases, no one gene has the yes/no power to say whether a person has a disease or not. It is likely that more than one mutation is required before the disease is manifest, and a number of genes may each make a subtle contribution to a person's susceptibility to a disease; genes may also affect how a person reacts to environmental factors.

Related Conferences: International Conference on Synthetic Biology, September 28-30, 2015 (Houston, USA); 6th World Congress on Biotechnology, October 05-07, 2015 (New Delhi, India); 3rd International Conference on Genomics & Pharmacogenomics, September 21-23, 2015 (San Antonio, USA); World Bio Summit & Expo, November 02-04, 2015 (Dubai, UAE); International Conference on Genetic Counselling And Genomic Medicine, August 11-12, 2016 (Birmingham, UK); Cell Symposia: Stem Cell Epigenetics 20-22 September 2015 (Barcelona, Spain); EMBO Conference The DNA damage response in cell physiology and disease 5-9 October 2015 (Cape Sounio, Greece); EMBO Conference Nuclear structure and dynamics 7-11 October 2015 (L'Isle-sur-la-Sorgue, France); CSH Asia Mitochondria 12-16 October 2015 (Cold Spring Harbour, New York); ABCAM Chromatin Structure and Function 16-19 November 2015 (Grand Cayman Island).

A genetic disorder is a genetic problem caused by one or more abnormalities in the genome, especially a condition that is present from birth. A genetic disease is any disease that is caused by an abnormality in an individual's genome, the person's entire genetic makeup. The abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosome abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. For example, for the gene that determines eye colour, you may inherit a brown allele from your mother and a blue allele from your father. In this instance, you will end up with brown eyes because brown is the dominant allele.

  • Single gene inheritance/ monogenetic disorders
  • Multifactorial inheritance
  • Chromosome abnormalities

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