Genetics and Transplantation of Diabetes

The estimated heritability of the metabolic syndrome and related metabolic traits (including obesity, dyslipidemia, abnormal glucose regulation and elevated blood pressure) is relatively high. Genetically modified knockout mice models and human monogenic obese/insulin resistant syndrome provide important molecular insights into the pathogenesis of the metabolic syndrome. Transplantation is the transfer (engraftment) of human cells, tissues or organs from a donor to a recipient with the aim of restoring function in the body. Transplantation can be of various types such as pancreas transplantation, xenotransplantation and islet transplantation. A pancreas transplant is surgery to implant a healthy pancreas from a donor into a patient with diabetes.

Several factors have to come together for a person to develop type 2 diabetes. Elements like nutrition and exercise are extremely important. However, type 2 diabetes also has a strong hereditary component.not all of your type 2 diabetes risk is genetic. Major risk factors for type 2 diabetes also include obesity and a sedentary lifestyle.Several gene mutations have been associated with type 2 diabetes risk. None of these genes cause diabetes on their own. Instead, they interact with environmental factors for instance, toxins, viruses, and foods — and each other to increase your risk.
 
  • Genetics of metabolic syndrome: Challenges and relation with diabetes mellitus
  • Diabetes in specific ethnic groups
  • Recent advances in genetics of diabetes
  • Pancreatic islet transplantation
  • Conventional insulinotherapy
  • Xenotransplantation
  • Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
  • Rodent Models of Diabetes

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